Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis
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منابع مشابه
Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis
OBJECTIVES Esculetin (6,7-dihydroxycoumarin) is a natural coumarin with anti-oxidant, anti-inflammatory and anti-nociceptive activity. It acts as a potent inhibitor of lipoxygenases (5-LOX and 12-LOX) and decreases the production of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9). Because both inhibition of lipoxygenases and inhibition of matrix metalloproteinases are effective strategies in...
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This study aimed to check the involvement of lipid mediator leukotriene (LT) B4 and the activity of LTA4 hydrolase (LTA4H) in the development of arthritis induced in rats by collagen and adjuvant (CIA). High-performance liquid chromatography (HPLC) and enzyme immunoassay (EIA) were used for measurements of LTB4 and LTA4H in plasma, synovial fluid (SF), soluble (SO), and solubilized membrane-bou...
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ژورنال
عنوان ژورنال: Reumatologia/Rheumatology
سال: 2016
ISSN: 0034-6233
DOI: 10.5114/reum.2016.62469